Biodegradable Polymers for Microencapsulation Systems

Figure 39

Cumulative release of leuprolide from all formulations of spray-dried microspheres and the Lupron Depot® (LD). Microspheres were incubated in PBST (pH 7.4) at 37°C. Panels are grouped according to formulations with varied spray drying parameters, including inlet air temperature (, a), PLGA concentration (, b), airflow in nozzle (, c), ratio between atomization gas flow rate and the liquid mass flow rate (, d), nozzle size (, e), and initial sample temperature (, f). The basic formulation (orange symbols) and LD are listed in each panel as controls. Symbols represent ( [116]).

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(b)

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