Anesthesiology Research and Practice / 2011 / Article / Tab 1

Review Article

Perspectives on the Role of Fospropofol in the Monitored Anesthesia Care Setting

Table 1

Key clinical trials evaluating the use of fospropofol as an agent in MAC sedation.

Study 𝑛 ProcedurePretreatmentDose (mg/kg) of fospropofolOther agents?Conclusions

Cohen 2008 [69]127Colonoscopy50 μg fentanyl2, 5, 6.5, or 8.0Midazolam as reference (0.02 mg/kg)Significant dose-dependent increases in sedation

Cohen et al. 2010 [70]314Colonoscopy50 μg fentanyl2.0 or 6.5Midazolam (0.02 mg/kg)Significantly greater sedation success, greater memory retention, and higher physician satisfaction at 6.5 than 2.0 mg/kg of fospropofol

Silvestri et al. 2009 [71]252Flexible bronchoscopy50 μg fentanyl2 or 6.5NoSignificantly higher sedation success at 6.5 mg/kg (88.7% versus 27.5%, 𝑃 < . 0 0 1 )

Rex et al. 2007, Safety and Efficacy [72]314Colonoscopy50 μg fentanyl2.0 or 6.5Midazolam (0.02 mg/kg)Significantly higher sedation success at 6.5 mg/kg (87% versus 26%, 𝑃 < . 0 0 1 ) with significantly greater depth of sedation

Rex et al. 2007, Clear-headed recovery [73]314Colonoscopy50 μg fentanyl2.0 or 6.5Midazolam (0.02 mg/kg)Fospropofol patients (both doses) had significantly higher mean percentage of retention postprocedure than midazolam ( 𝑃 < . 0 0 1 )