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Anesthesiology Research and Practice
Volume 2011, Article ID 579038, 4 pages
http://dx.doi.org/10.1155/2011/579038
Clinical Study

Efficacy and Tolerability of Intramuscular Dexketoprofen in Postoperative Pain Management following Hernia Repair Surgery

1Department of Surgery, Dr. Shankarrao Chavan Government Medical College & Hospital, Nanded, Maharashtra 431601, India
2Sharada Clinic, Pune, Maharashtra 411042, India
3Dr. Kenekar's Noble Hospital & Research Centre, Ahmednagar, Maharashtra 414001, India
4Sharada Clinic, Erram Hospital, Karad, Maharashtra 415110, India
5Department of Surgery, Karnataka Institute of Medical Sciences, Hubli, Karnataka 580022, India
6Shashwat Hospital, Pune, Maharashtra 411028, India
7Dr. R. N. Cooper Municipal General Hospital, Vile Parle West, Mumbai, Maharashtra 400056, India
8Shree Hospital, Siddharth Mansion, Nagar Road, Pune, Maharashtra 411014, India
9Shri Venkatesh Hospital, Barshi Road, Latur, Maharashtra 413512, India
10Criticare Hospital, JVPD Scheme, Andheri West, Mumbai, Maharashtra 400049, India
11Sahyadri Speciality Hospital, Karve Road, Pune, Maharashtra 411004, India
12Department of Pharmacology, Dr. Shankarrao Chavan Government Medical College & Hospital, Nanded, Maharashtra 431601, India

Received 10 December 2010; Accepted 14 March 2011

Academic Editor: Audun Stubhaug

Copyright © 2011 P. T. Jamdade et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the safety and efficacy of intramuscular dexketoprofen for postoperative pain in patients undergoing hernia surgery. Methodology. Total 202 patients received single intramuscular injection of dexketoprofen 50 mg or diclofenac 50 mg postoperatively. The pain intensity (PI) was self-evaluated by patients on VAS at baseline 1, 2, 4, 6, and 8 hours. The efficacy parameters were number of responders, difference in PI (PID) at 8 hours, sum of analogue of pain intensity differences (SAPID), and onset and duration of analgesia. Tolerability assessment was done by global evaluation and adverse events in each group. Results. Dexketoprofen showed superior efficacy in terms of number of responders (), PID at 8 hours (), and SAPID0–8 hours (). It also showed faster onset of action (42 minutes) and longer duration of action (6.5 hours). The adverse events were comparable in both groups. Conclusion. Single dose of dexketoprofen trometamol 50 mg given intramuscularly provided faster, better, and longer duration of analgesia in postoperative patients of hernia repair surgery than diclofenac 50 mg, with comparable safety.