Research Article
Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats
| Measures | Groups | P | Fentanyl | Saline | Unoperated |
| Weight PND 21, mean (±SD), g | 43 (±3)*§ | 36 (±6)* | 36 (±4)§ |
*F versus S =.001; | §F versus Un <.001; | Eye opening score, PND 14, median (IQR) | 2 (1-2) | 1 (0–2) | 0 (0–2) | NS | Open field, line crossing, mean (±SD) | 68 (±23) | 62 (±24) | 48 (±27) | NS | Latency time wire, median (IQR), sec: | | | | | PND 18 | 127 (20–183)* | 183 (183-183)* | 183 (162–183) |
*F versus S =0.035 | PND 20 | 25 (15–98) | 75 (12–183) | 76 (9–183) | NS | Recognition index, mean (±SD) | 0.8 (±0.3)* | 0.6 ± (0.3)*§ | 0.8 (±0.2)§ |
*F versus S =0.045; | §Un versus S =0.025 | Time (%) spent open arms, median (IQR) | 18 (17–32)*§ | 7 (3–17)* | 10 (7–16)§ |
*F versus S =0.034; | §F versus Un =0.045 | Best latency time fall rod, mean (±SD), sec | 173 (±24)*§ | 123 (±73)* | 128 (±24)§ |
*F versus S =0.022; | §F versus Un =0.04 |
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PND: postnatal day; IQR: interquartile range; P: significance for independent samples: NS: nonsignificant; F: Fentanyl; S: Saline; Un: Unoperated.
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