Perioperative Anesthesiological Management of Patients with Pulmonary Hypertension

Table 4

Therapy of pulmonary hypertension: approved drugs (mod. [8]).

Drug		Dosage	Side effect
Bosentan	Endothelin receptor antagonist	2 × 62,5–125 mg/d po	Increase of liver enzymes edema
Ambrisentan	Selective endothelin-A; Receptor-antagonist	1 × 5–10 mg/d po	Increase of liver enzymes; edema
Sildenafil	PDE-5 inhibitor	3 × 20 mg/d po	Reflux esophagitis
Tadalafil	PDE-5 inhibitor	1 × 40 mg/d po	Headache and pain in the limbs
Iloprost	Prostacyclin-analog	6–9 × 2,5/5 μg inhalative	Hypotension and flush
Treprostinil	Prostacyclin-analog	1,25–22,5 ng/kg/min s.c.	Local pain