The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Trial

Table 2

The multivariate mean difference of systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate by treatment group adjusted for multiple variables^†.

	Difference*	𝑃 value	95% CI
Systolic blood pressure (mmHg)	15.2	<0.001	6.9–23.6
Diastolic blood pressure (mmHg)	10.5	<0.001	5.6–15.3
Mean arterial pressure (mmHg)	14.0	<0.001	7.4–20.6
Heart rate (beats per minute)	10.5	<0.001	6.2–14.8
Rate pressure product (mmHg min^−1)	2,462.8	<0.001	1,415.7--3,510.0

The mean difference of each hemodynamic variable was estimated from hemodynamic change between baseline, before intubation, during intubation, and T1–T10.
^†Adjusted for age, gender, ASA classification, preexisting hypertension, baseline hemodynamic variables, intubation time, and intubation attempts.
*Placebo group-treatment group.