Phenoxybenzamine in Complex Regional Pain Syndrome: Potential Role and Novel Mechanisms

Table 1

Summary of clinical trials of phenoxybenzamine for treatment of CRPS.

Predominant syndrome	Total number of patients	Target daily dose range (mg)	Number with favorable clinical outcome	Reference
CRPS II; causalgia	15	40–160	11	Moser et al., 1953 [13]
CRPS II; causalgia	40	40–120	40	Ghostine et al., 1984 [14]
CRPS I	1	20	1	Lefkoe and Cardenas, 1996 [16]
CRPS I and II	33	120	17	Muizelaar et al., 1997 [15]
CRPS I	5	5	5	Malik et al., 1998 [17]
CRPS I	4	3–10	3	Inchiosa and Kizelshteyn, 2008 [19]