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Anesthesiology Research and Practice
Volume 2014, Article ID 170247, 6 pages
Clinical Study

Attenuation of Hemodynamic Responses to Laryngoscopy and Tracheal Intubation: Propacetamol versus Lidocaine—A Randomized Clinical Trial

1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, IL 60612, USA
2Department of Anaesthesiology, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran
3Department of Epidemiology of Biostatistics, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran
4Department of Dermatology, Golestan University of Medical Sciences, Gorgan 4934174515, Iran
5Zainaldin Martyr Research Center, Gorgan University of Agricultural Sciences and Natural Resources, P.O. Box 15739-49138, Gorgan, Iran
6Center for Cardiovascular Research, University of Illinois at Chicago, 835 S. Wolcott Avenue, Chicago, IL 60612, USA

Received 2 February 2014; Accepted 26 March 2014; Published 13 April 2014

Academic Editor: D. John Doyle

Copyright © 2014 Ali Kord Valeshabad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this study is to assess the effects of propacetamol on attenuating hemodynamic responses subsequent laryngoscopy and tracheal intubation compared to lidocaine. In this randomized clinical trial, 62 patients with the American Anesthesiologists Society (ASA) class I/II who required laryngoscopy and tracheal intubation for elective surgery were assigned to receive propacetamol 2 g/I.V./infusion (group P) or lidocaine 1.5 mg/kg (group L) prior to laryngoscopy. Systolic and diastolic blood pressures (SBP, DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded at baseline, before laryngoscopy and within nine minutes after intubation. In both groups P and L, MAP increased after laryngoscopy and the changes were statistically significant ( ). There were significant changes of HR in both groups after intubation ( ), but the trend of changes was different between two groups ( ). In group L, HR increased after intubation and its change was statistically significant within 9 minutes after intubation ( ), while in group P, HR remained stable after intubation ( ). Propacetamol 2 gr one hour prior intubation attenuates heart rate responses after laryngoscopy but is not effective to prevent acute alterations in blood pressure after intubation.