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Anesthesiology Research and Practice
Volume 2015, Article ID 306145, 6 pages
Clinical Study

Effect of Low-Dose (Single-Dose) Magnesium Sulfate on Postoperative Analgesia in Hysterectomy Patients Receiving Balanced General Anesthesia

1Department of Anesthesiology and Pain Medicine, Tehran University of Medical Science, Tehran 19986 35696, Iran
2Department of Anesthesiology, Reproductive Health Research Center, Guilan University of Medical Sciences, Guilan 14455 41656, Iran
3Department of Gynecology, Reproductive Health Research Center, Guilan University of Medical Sciences, Guilan 14455 41656, Iran
4Department of Internal Medicine, Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin 14816 46341, Iran

Received 7 July 2014; Revised 16 December 2014; Accepted 15 January 2015

Academic Editor: Yukio Hayashi

Copyright © 2015 Arman Taheri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aim. Aparallel, randomized, double blinded, placebo-controlled trial study was designed to assess the efficacy of single low dose of intravenous magnesium sulfate on post-total abdominal hysterectomy (TAH) pain relief under balanced general anesthesia. Subject and Methods. Forty women undergoing TAH surgery were assigned to two magnesium sulfate () and normal saline () groups randomly. The magnesium group received magnesium sulfate 50 mgkg−1 in 100 mL of normal saline solution i.v as single-dose, just 15 minutes before induction of anesthesia whereas patients in control group received 100 mL of 0.9% sodium chloride solution at the same time. The same balanced general anesthesia was induced for two groups. Pethidine consumption was recorded over 24 hours precisely as postoperative analgesic. Pain score was evaluated with Numeric Rating Scale (NRS) at 0, 6, 12, and 24 hours after the surgeries. Results. Postoperative pain score was lower in magnesium group at 6, 12, and 24 hours after the operations significantly (). Pethidine requirement was significantly lower in magnesium group throughout 24 hours after the surgeries (). Conclusion. Single dose of magnesium sulfate during balanced general anesthesia could be considered as effective and safe method to reduce postoperative pain and opioid consumption after TAH.