Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction
Table 1
Patients’ characteristics.
Total
On-pump surgery
Off-pump surgery
p value
Number of patients
80
51
29
Chi-square test
Male/female (male%)
57/23 (71%)
34/17 (67%)
23/6 (79%)
0.92
Kruskal-Wallis test
Age (year)
68 (58–74)
67 (53–74)
70 (60–74)
0.08
Body weight (kg)
60 (53–68)
59 (53–68)
61 (57–68)
0.54
White blood cell count (cells/mm3)
5840 (4850–7100)
5600 (4815–7100)
5950 (4900–6900)
0.70
Hemoglobin (g/dL)
12.7 (11.5–13.5)
12.4 (11.4–13.3)
13.1 (11.8–13.7)
0.13
Platelet count (104/mm3)
19.1 (15.5–23.8)
18.5 (14.8–23.1)
20.7 (16.5–25.6)
0.21
Total protein (g/dL)
7.2 (6.6–7.4)
7.2 (6.7–7.3)
7.2 (6.6–7.6)
0.13
Albumin (g/dL)
4.1 (3.8–4.4)
4.2 (4.0–4.4)
4.0 (3.8–4.3)
0.21
BUN (mg/dL)
18.0 (14–22)
17.5 (14.0–21.9)
18.4 (15.4–22.0)
0.59
Creatinine (mg/dL)
0.95 (0.75–1.2)
0.92 (0.76–1.1)
0.97 (0.75–1.2)
0.83
Mean blood pressure (mmHg)
90 (82–98)
85 (78–96)
94 (87–103)
0.006
Heart rate (beats/min)
70 (62–78)
69 (62–77)
70 (61–79)
0.96
PaO2/ ratio
427 (331–500)
417 (342–500)
428 (327–490)
0.97
Duration of surgery (min)
385 (315–450)
405 (346–486)
320 (254–391)
0.0004
Duration of cardiopulmonary bypass (min)
197 (160–254)
Transfusion
Red cell ()
0 (0–4)
2 (0–4)
0 (0–2)
0.09
Fresh frozen plasma ()
0 (0–6)
0 (0–8)
0 (0–0)
0.001
Platelet ()
0 (0–0)
0 (0–20)
0 (0–0)
0.001
Values are median (interquartile range). unit of packed red cells or fresh frozen plasma was derived from 200 mL of donated blood. unit of packed platelet concentrate contained 2 × 1010 platelets. BUN: blood urea nitrogen.
