Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction
Table 2
Characteristics of patients with or without acute kidney injury.
AKI
Non-AKI
p value
Number of patients
22
58
Chi-square test
Male sex
17 (77%)
40 (69%)
0.54
Diabetes mellitus
5 (22.7%)
20 (34.5%)
0.4
Type of surgery (on-pump/off-pump)
19/3
33/25
0.002
Mann–Whitney U test
Age (year)
68 (61–74)
67 (56–74)
0.66
Body weight (kg)
62 (58–68)
60 (53–68)
0.31
Creatinine at baseline (mg/dL)
1.06 (0.88–1.20)
0.90 (0.74–1.11)
0.047
Data immediately after surgery
White blood cell count (cells/mm3)
10300 (8658–12800)
9980 (7875–13153)
0.95
Platelet count (104/mm3)
9.2 (8.2–10.5)
10.6 (7.8–14.6)
0.28
Albumin (g/dL)
3.5 (2.9–3.6)
3.2 (2.7–3.6)
0.22
PaO2/ ratio
245 (168–319)
279 (205–348)
0.17
Red cell transfusion ()
4 (2–4)
0 (0–4)
0.002
Serum interleukin-8 (pg/mL)
97 (41–173)
37 (2–62)
<0.001
Serum troponin-T (ng/mL)
0.70 (0.46–1.14)
0.39 (0.19–0.71)
0.02
Serum NT-proBNP (pg/mL)
329 (166–618)
137 (69–567)
0.04
Duration of surgery (min)
489 (400–580)
353 (295–410)
<0.001
Serum dsDNA concentration on POD-1 (ng/mL)
455 (351–503)
287 (238–356)
<0.001
unit of packed red cells or fresh frozen plasma was derived from 200 mL of donated blood. AKI: patients diagnosed with acute kidney injury. Non-AKI: patients without acute kidney injury. POD-1: postoperative day-1 (the day after surgery). OPCAB: off-pump coronary arterial bypass grafting. NT-proBNP: N-terminal pro-B-type natriuretic peptide.
