Study Participants Intervention Duration of surgery Intraabdominal pressure Control Rescue antiemetic Complications Outcome Source of bias
Alghanem et al. 2010 [5 ] ASA 1 and ASA 2 patients aged 18–70 years scheduled for elective laparoscopic cholecystectomy patients received 8 mg dexamethasone after induction44.5 18.1 min in dexamethasone group versus 41.2 13.4 in ondansetron group 10 to 16 mmHg patients received 4 mg ondansetron after inductionMetoclopramide 10 mg rescue dose, in patients with intractable nausea or lasting for at least 15 min, or at patients request anytime, or with vomiting No significant complications Episodes of PONV, nausea and vomiting at 0 to 4 h and 4 to 24 h intervals
D’souza et al. 2011 [6 ] Women aged 20–60 years with ASA grade I/II scheduled for gynecologic laparoscopic surgery patients received 8 mg dexamethasone before inductionActual value not reported, no difference in surgical time 10 to 14 mmHg patients received 4 mg ondansetron after inductionNausea/vomiting assessed with 4-point scale, retching considered as vomiting, rescue dose 10 mg metoclopramide intravenous Not reported Episodes of nausea and vomiting at 0–3 hours, 3–6 hours, 6–12 hours, and 12–24 hours Use of nitrous oxide, no mention about intraoperative opioid use
Erhan et al. 2008 [7 ] 80 ASA I or ASA II patients (61 women and 19 men), aged 21–75 years scheduled for laparoscopic cholecystectomy patients received 8 mg dexamethasone 15 minutes before induction72.0 43.6 min in dexa group versus 69.3 16.9 min ondansetron 12 mmHg patients received 4 mg ondansetron before inductionPONV recorded by nursing staff, both nausea and vomiting assessed, rescue antiemetic 10 mg metoclopramide intravenous No significant side-effects Incidence of nausea and vomiting was recorded during three assessment periods, 0–6 h, 6–12 h, and 12–24
Gautam et al. 2008 [8 ] 150 ASA I-II patients, aged between 23 and 65 years, undergoing elective laparoscopic cholecystectomy patients received dexamethasone 8 mg before induction of anaesthesia79.77 19 min in dexa group versus 77.69 19.0 Below 15 mmHg patients received 4 mg ondansetron before inductionPONV assessed by 3-point scale, 10 mg metoclopramide intravenous given when if 2 score points were reached or on patients demand No side-effects reported Incidence of nausea and vomiting till 24 h after surgery
Mendes et al. 2009 [9 ] 77 patients aged 20 to 56 years, ASA II, BMI ≥ 35 kg⋅m−2 undergoing videolaparoscopic gastroplasty patients received 0.1 mg⋅kg−1 of dexamethasone corrected for body weight up to a maximum of 10 mg122.5 38.73 min in dexa group versus 153 45.86 Not mentioned patients received 0.1 mg⋅kg−1 of ondansetron up to a maximum of 8 mgBlinded anesthesiologist, administered 50 mg in presence of nausea or vomiting No side effects reported Incidence of nausea vomiting up to 24 h after surgery Use of intraoperative morphine
Gupta et al. 2006 [10 ] 100 adult patients undergoing laparoscopic cholecystectomy patients received dexamethasone 5 mg 90 minutes before induction of anaesthesia20–60 (48) min dexa group versus 20–55 (46) min in ondansetron group 12 mmHg patients received ondansetron 4 mg 90 minutes before induction of anaesthesiaOndansetron 4 mg intravenously irrespective of the group if patients develop nausea or vomiting, administered by house staff No postoperative complication reported Incidence of nausea vomiting up to 48 h after surgery
Yuksek et al. 2003 [11 ] ASA PS I or II patients, aged 19–62 years and undergoing elective gynaecological laparoscopy patients received dexamethasone 8 mg50.3 (14–98) min in dexa group versus 62.1 (23–90) min in ondansetron group 12–18 min patients received ondansetron 4 mgNausea vomiting assessed by 3-point ordinal scale, rescue 10 mg metoclopramide intravenous by blinded investigator No complication was reported Incidence of PONV immediately after surgery and at 15 min intervals for 3 h, every 30 min for 3 h, and then every 3 h for 18 h