Injectable Anesthesia for Mice: Combined Effects of Dexmedetomidine, Tiletamine-Zolazepam, and Butorphanol

Table 3

Trials with dexmedetomidine, tiletamine-zolazepam, and butorphanol (DTZB). Dexmedetomidine and tiletamine-zolazepam were administered IP and butorphanol was administered at 3 mg/kg SC. Data is reported in marginal means and standard error.

	Anesthetic duration (minutes)	Recovery time (minutes)	Anesthesia achieved (%)	Heart rate (bpm)	Respiratory rate (bpm)
Dexmedetomidine 0.2 mg/kg
Tiletamine-zolazepam
10 mg/kg	28 (±21)	105 (±16)	50% (3/6)	188 (±12)	132 (±4)
20 mg/kg	73 (±16)	168 (±16)	100% (6/6)	191 (±12)	137 (±4)
40 mg/kg	143 (±16)	217 (±16)	100% (6/6)	198 (±12)	137 (±4)
Dexmedetomidine 0.4 mg/kg
Tiletamine-zolazepam
10 mg/kg	90 (±18)	161 (±16)	33% (2/6)	199 (±12)	129 (±4)
20 mg/kg	110 (±16)	224 (±16)	100% (6/6)	202 (±12)	134 (±4)
40 mg/kg	163 (±16)	273 (±16)	100% (6/6)	209 (±12)	134 (±4)
Dexmedetomidine 0.6 mg/kg
Tiletamine-zolazepam
10 mg/kg	80 (±16)	213 (±16)	100% (6/6)	195 (±12)	131 (±4)
20 mg/kg	195 (17)	276 (±17)	100% (6/6)	198 (±12)	136 (±4)
40 mg/kg	216 (±16)	325 (±16)	100% (6/6)	205 (±12)	136 (±4)