Review Article

Intravenous Magnesium Sulphate for Analgesia after Caesarean Section: A Systematic Review

Table 2

Included trials, participants, interventions, and outcomes.

Total (n)Anaesthetic typeIntervention groups (n)Outcomes

Elgebaly et al., 2011, Egypt90Spinal(i) IV magnesium sulphate bolus and 24 hr infusion (30)(i) Total 24 hr analgesia use (paracetamol)
(i) Bupivacaine 0.5% (2 mL)(ii) 25 µg in 1 mL intrathecal fentanyl plus + NS IV (30)(ii) Time to first analgesia
(iii) Normal saline control (30)(iii) Pain (VAS) score

Helmy et al., 2015, Egypt60General(i) IV magnesium sulphate bolus (20)(i) Intraop analgesia requirement (fentanyl)
(i) Thiopental 5 mg/kg(ii) Ketamine 0.3 mg/kg (20)(ii) Time to first analgesia
(ii) Fentanyl 100 μg at delivery(iii) 20 mL normal saline control (20)(iii) Pain (VAS) score

Elrahman and Youssry, 2017, Egypt90General(i) IV magnesium sulphate bolus (30)(i) Total 24 hr analgesia use (morphine)
(i) IV propofol 2 mg/kg(ii) Normal saline control (30)(ii) Time to first analgesia
(ii) IV midazolam 1 mg and fentanyl 1 μg/kg at delivery(iii) Pain (VAS) score
(iv) Time to ambulation

Maulik et al., 2015, India80Spinal(i) IV magnesium sulphate bolus and 24 hr infusion (40)(i) Rescue analgesia consumption (diclofenac)
(i) Bupivacaine 0.5%(ii) Normal saline control (40)(ii) Time to first analgesia
(iii) Pain (VAS) scores

Mireskandari et al., 2015, Iran50General(i) IV magnesium sulphate bolus (25)(i) Total 24 hr PCA consumption (morphine)
(i) Thiopental 4 mg/kg(ii) Normal saline control (25)(ii) Pain (VAS) score
(ii) Fentanyl 1 μg/kg and midazolam 1 mg at delivery

Paech et al., 2006, Australia120Spinal-epidural(i) IV magnesium sulphate bolus and 24 hr infusion (42). High dose: 50 mg/kg and 2 g/hr(i) Total analgesia consumption (meperidine)
(i) Bupivacaine 0.5%(ii) IV magnesium sulphate bolus and 24 hr infusion (38). Low dose: 25 mg/kg and 2 g/hr(ii) Time to first analgesia
(ii) Fentanyl 15 μg(iii) Normal saline control (40)(iii) Pain (VAS) score

Rezae et al., 2014, Iran70General(i) Magnesium sulphate 50 mg/kg in 100 mL NS bolus (35)(i) Total 24 hr analgesia consumption (morphine)
(i) Thiopental 6 mg/kg
(ii) Fentanyl 2 μg/kg(ii) Normal saline control (35)(ii) Pain (VAS) score
(iii) Morphine 0.15 mg/kg after delivery

530Receiving magnesium (260)

IV = intravenous, hr = hours, VAS = visual analogue scale, PCA = patient controlled analgesia.