Subparalyzing Doses of Rocuronium Reduce Muscular Endurance without Detectable Effect on Single Twitch Height in Awake Subjects

Table 1

Effect of placebo and different doses of rocuronium on sustained force (median (range)).

Time (s)	Placebo (N)	Rocuronium 0.04 mg/kg (N)	Rocuronium 0.08 mg/kg (N)
Max. force	360 (198–483)	352 (257–405) n.s.	317 (199–364) n.s.
10	260 (154–363)	256 (210–316)	240 (200–342)
20	246 (153–298)	222 (141–314)	194 (168–285)
30	234 (126–282)	222 (157–257)	149 (125–247)
40	222 (129–310)	217 (145–269)	126 (80–215)
50	203 (138–290)	216 (155–248)	92 (54–159)
60	214 (120–278)	187 (124–256)	69 (30–166)
70	208 (120–254)	175 (127–218)	47 (33–127)

n.s., not significant; ; as compared with placebo. The Wilcoxon signed-rank test was used.