Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia

Figure 2

Comparison of the observed plasma dexmedetomidine time course (OBS, open circles) to typical subject prediction (PRED, black solid line) and individual-level prediction (IPRED, black dash line) based on the respective population model. Predictions based on the naïve pooled compartmental model (blue solid line) are overlaid for comparison. Body weight-normalized dexmedetomidine-infused rates, which varied across subjects, are also depicted (red dotted-dash line). Upper and lower panels present the respective semilogarithmic and rectilinear plots; the former is better in showing the model fit to data in the postinfusion phase, whereas the latter shows the fit during infusion more clearly. Variation in the infusion regimen across the subjects is also more evident in the rectilinear plots.

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