Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia

Figure 4

Visual predictive check (VPC) plot of the final dexmedetomidine population model providing a comparison of observed and predicted data. Individual concentrations are depicted using black points, with the median for the observed concentration-time course being depicted as a solid red line and its simulated 5th and 95th percentiles. The median for model predictions is depicted as a black solid line, with corresponding simulated 5th and 95th percentiles being depicted as a dotted black line. The simulated 90% prediction intervals for the 5th, 50th, and 95th levels are depicted using light blue polygons (prediction area overlaps appear as darker polygons).