The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials

Table 1

Summary of study characteristics included in analysis.

Authors	Year of publication	Procedures	Number treatment/control	Treatment	Administration time	Method of extraction
Carvalho et al [20]	2018	Coronary artery bypass grafting	31/31	0.1 mg/kg methadone; 0.1 mg/kg morphine	Induction	Text; Table
Chui and Gin [21]	1992	Abdominal; Hysterectomies	15/15	0.25 mg/kg methadone; 0.25 mg/kg morphine	Induction	Text; Table
Gourlay et al [22]	1986	Cholecystectomy; Vagotomy; Nissen fundoplication	10/10	0.3 mg/kg morphine; 0.3 mg/kg methadone	10 min after induction	Text; Table
Laur et al [23]	1995	Orthopedic surgery	15/15	0.3 mg/kg methadone; 0.3 mg/kg morphine	25% patient positioning; 50% induction; 25% before incision	Text; Table
Moro et al [24]	2019	Laparoscopic; Cholecystectomy	50/50	0.1 mg/kg methadone; 0.1 mg/kg morphine	End of anesthesia	Text; Table
Richlin and Reuben [25]	1991	Lower abdominal surgery	20/20	0.3 mg/kg morphine; 0.3 mg/kg methadone	Right after induction	Text; Table
Udelsmann et al [26]	2011	Cardiac surgery with extracorporeal circulation	18/19/18	0.3 mg/kg methadone; 0.3 mg/kg morphine; 2 mL normal saline	Induction	Table; Text