Review Article
The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials
Table 1
Summary of study characteristics included in analysis.
| Authors | Year of publication | Procedures | Number treatment/control | Treatment | Administration time | Method of extraction |
| Carvalho et al [20] | 2018 | Coronary artery bypass grafting | 31/31 | 0.1 mg/kg methadone 0.1 mg/kg morphine | Induction | Text Table | Chui and Gin [21] | 1992 | Abdominal Hysterectomies | 15/15 | 0.25 mg/kg methadone 0.25 mg/kg morphine | Induction | Text Table | Gourlay et al [22] | 1986 | Cholecystectomy Vagotomy Nissen fundoplication | 10/10 | 0.3 mg/kg morphine 0.3 mg/kg methadone | 10 min after induction | Text Table | Laur et al [23] | 1995 | Orthopedic surgery | 15/15 | 0.3 mg/kg methadone 0.3 mg/kg morphine | 25% patient positioning; 50% induction; 25% before incision | Text Table | Moro et al [24] | 2019 | Laparoscopic Cholecystectomy | 50/50 | 0.1 mg/kg methadone 0.1 mg/kg morphine | End of anesthesia | Text Table | Richlin and Reuben [25] | 1991 | Lower abdominal surgery | 20/20 | 0.3 mg/kg morphine 0.3 mg/kg methadone | Right after induction | Text Table | Udelsmann et al [26] | 2011 | Cardiac surgery with extracorporeal circulation | 18/19/18 | 0.3 mg/kg methadone 0.3 mg/kg morphine 2 mL normal saline | Induction | Table Text |
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