Research Article

Prevention of Postoperative Events following Reversal with Sugammadex or Neostigmine (the P-PERSoN Trial): Pilot Data Following Early Termination of a Prospective, Blinded, Randomised Trial

Table 1

Definitions used for outcome measurements and risk stratification.

European perioperative clinical outcome (EPCO) definitions of postoperative pulmonary complications [18]
Respiratory infectionPatient has received antibiotics for suspected respiratory infection and met one or more of the following criteria: new or changed sputum, new or changed lung opacities, fever, white blood cell count > 12 × 109/litre
Respiratory failurePostoperative PaO2 < 60 mm·Hg on room air, PaO2 : FiO2 ratio < 300 mm·Hg), or arterial oxyhaemoglobin saturation measured with pulse oximetry < 90% and needing oxygen therapy
Pleural effusionChest radiograph showing blunting of costophrenic angle, loss of sharp silhouette of ipsilateral hemidiaphragm in upright position, evidence of displacement of adjacent anatomical structures, or (in supine position) hazy opacity in one hemithorax with preserved vascular shadows
AtelectasisLung opacification with shift of mediastinum, hilum, or hemidiaphragm towards affected area, and compensatory over-inflation in adjacent nonatelectatic lung
PneumothoraxAir in pleural space with no vascular bed surrounding visceral pleura

Assess respiratory risk in surgical patients in catalonia (ARISCAT) score for risk prediction of postoperative pulmonary complications [17]
Risk factorScore
Age 51–803
Age > 8016
Preoperative SpO2 91–95%8
Preoperative SpO2 ≤ 90%24
Respiratory infection in past 1 month17
Preoperative haemoglobin < 10 gm/dl11
Upper abdominal incision15
Intrathoracic incision24
Surgery duration 2-3 hours16
Surgery duration > 3 hours23
Emergency procedure8
Total score-low risk: <26, intermediate risk: 26–44, high risk: ≥45

Apfel score for risk prediction of PONV [20]
Risk factors (1 point each) – female sex, history of ponv or motion sickness, nonsmoker, postoperative opioid treatment planned.
Total score and risk stratification
0Minimal risk
1Low risk
2Intermediate risk
3High risk
4Very high risk

Definitions of postoperative care unit events
PACU events
(i) Any desaturation to SpO2 < 90%
(ii) Need for manual airway support
(iii) Need for oropharyngeal or nasopharyngeal airway
(iv) Need for reintubation in PACU
(v) Need for anaesthetist to review the patient
(vi) Unplanned ICU admission
PONV score
1. No PONV
2. PONV responsive to antiemetics
3. PONV unresponsive to antiemetics

PaO2, partial pressure of arterial oxygen; FiO2, fraction of inspired oxygen; SpO2, peripheral capillary oxygen saturation; PONV, postoperative nausea and vomiting; PACU–post anaesthesia care unit; ICU, intensive care unit.