A Randomized Controlled Trial for Prevention of Postspinal Anesthesia Shivering in Gynecological Surgeries: Mirtazapine vs. Dexamethasone
Table 1
Patients’ demographics and perioperative data.
Items
M group (n = 100)
D group (n = 100)
C group (n = 100)
value
Age (year)
44.3 ± 7.9
44.8 ± 7.4
42.8 ± 7.2
^0.140
BMI (kg/m2)
30.4 ± 1.5
30.5 ± 1.6
30.2 ± 1.7
^0.288
ASA (I/II)
26/74
27/73
29/71
#0.889
Dose of bupivacaine (mg)
14.9 ± 1.9
15.1 ± 1.9
15.4 ± 2.1
^0.199
Operation time (min)
113.9 ± 14.4
113.6 ± 13.6
112.5 ± 13.7
^0.761
Types of operations; n, %
(i) Total abdominal hysterectomy (TAH)
14 (14%)
13 (13%)
12 (12%)
#0.998
(ii) TAH + BSO
40 (40%)
41 (41%)
39 (39%)
(iii) Vaginal hysterectomy (VH)
9 (9%)
10 (10%)
8 (8%)
(iv) VH + PFR
27 (27%)
26 (26%)
28 (28%)
(v) Vesicovaginal fistula repair
10 (10%)
10 (10%)
13 (13%)
Preoperative Hb (g/dl)
11.5 ± 0.4
11.5 ± 0.4
11.6 ± 0.4
^0.141
Postoperative Hb (g/dl)
9.3 ± 0.5
9.3 ± 0.4
9.4 ± 0.4
^0.342
Total IV fluids used (ml)
2035.0 ± 111.4
2007.0 ± 117.4
2023.0 ± 116.2
^0.227
Characteristics of neuraxial anesthesia techniques
Peak sensory level
T5 (T4–T8)
T6 (T4–T8)
T6 (T4–T8)
§0.389
Time to peak sensory level (min)
6.5 ± 0.6a
4.6 ± 0.6b
6.7 ± 0.6a
^<0.001
Time to two-segment regression (min)
63.2 ± 1.7a
77.1 ± 1.4b
69.3 ± 1.2c
^<0.001
Time to reach maximum motor block (min)
9.2 ± 0.4
9.1 ± 0.5
9.2 ± 0.4
^0.062
Duration of motor block (min)
135.2 ± 2.4
135.9 ± 2.2
135.4 ± 2.3
^0.065
Time to rescue analgesia (min)
173.9 ± 4.1a
321.3 ± 4.8 b
215.8 ± 4.4c
^<0.001
Data were presented as median (range), mean (SD), numbers, and percent. ^ANOVA test, #chi square test, and §Kruskal Wallis test. Labels (a, b, c) denote homogenous groups depending on post hoc Bonferroni test. Statistically significant. TAH + BSO: total abdominal hysterectomy with a bilateral salpingo-oophorectomy. PFR: pelvic floor repair. M group: mirtazapine group; D group: dexamethasone group; C group: control group.
