A Randomized Controlled Trial for Prevention of Postspinal Anesthesia Shivering in Gynecological Surgeries: Mirtazapine vs. Dexamethasone
Table 3
Side effects, administered treatments, and patient satisfaction score.
Time points
M group (n = 100)
D group (n = 100)
C group (n = 100)
value
Bradycardia; n,%
6 (6%)
8 (8%)
7 (7%)
#0.858
Hypotension; n,%
6 (6%) a
8 (8%) a
25 (25%) b
#<0.001
Need for ephedrine; n, %
27 (27%) a
32 (32%) a
78 (78%) b
#<0.001
Ephedrine dose (mg)
10.3 ± 3.1 a
13.5 ± 4 a
21.4 ± 6.9 b
^<0.001
Pruritus; n, %
2 (2%) a
10 (10%) a
24 (24%) b
#<0.001
Nausea; n, %
4 (4%) a
5 (5%) a
28 (28%) b
#<0.001
Vomiting; n, %
2 (2%) a
3 (3%) a
17 (17%) b
#<0.001
Rescue antiemetic; n, %
3 (3%) a
4 (4%) a
22 (22%) b
#<0.001
Sedation; n, %
(i) I
7 (7%) a
100 (100%) b
100 (100%)b
#<0.001
(ii) II
85 (85%)
0 (0)
0 (0)
(iii) III
8 (8%)
0 (0)
0 (0)
(iv) IV
0 (0)
0 (0)
0 (0)
Headache; n, %
6 (6%)
4 (4%)
5 (5%)
#0.810
Dry mouth; n, %
22 (22%) a
8 (8%) b
10 (10%) b
#0.007
Elevated liver enzymes; n, %
3 (3%)
1 (1%)
1 (1%)
⌂0.625
Patient satisfaction score
5.0 (5-6) a
5.0 (4–6) a
2.0 (2-3) b
§<0.001
Data were presented as median (range), mean (SD), numbers, and percent. #Chi square test, ^ANOVA test, §Kruskal Wallis test, and ⌂Fisher’s exact test. Labels (a, b, c) denote homogenous groups depending on post hoc Bonferroni test. Statistically significant. M group: mirtazapine group; D group: dexamethasone group; C group: control group.
