Review Article

Effects of Preoperative Oral Carbohydrate on Perioperative Maternal Outcomes Undergoing Cesarean Section: A Systematic Review and Meta-Analysis

Table 1

Details of included studies.

Authors, yearCountryAnesthesiaCarbohydrate groupControl groupOutcomes
Placebo groupFasting group
Sample sizeInterventionSample sizeInterventionSample sizeIntervention

Ghorashi et al. 2014 [18]IranGeneral anesthesia267Oral 150 ml of 10% traditional sugar plum 1 h preoperatively144Received nothingRate of regurgitation and aspiration
Razieh Khalooei Fard, 2017IranSpinal anesthesia45Oral 800 ml of 12.5% carbohydrates (50 kcal/100 ml) between 20 and 24 hours before surgery and 400 ml of the same drink 2 hours before the anesthesia46Oral 800 ml of flavored water with lemon (0 kcal/100 ml) between 20 and 24 hours before surgery and 400 ml of the same drink 2 hours before the anesthesiaTime to first breastfeeding after surgery, frequency, and duration of breastfeeding for up to 36 hours after the surgery
Wendling et al. 2020 [23]USASpinal anesthesia15Oral 710 mL of 14% carbohydrates (56.3 kcal/100 mL) the evening prior to surgery and 355 mL 2–4 hours before the anesthesia start time17Oral 710 mL of 5.9% carbohydrates (22.5 kcal/100 mL) the evening prior to surgery and 355 mL 2–4 hours before the anesthesia15Fasted after midnight the night before surgery and no oral intake at least 8 hours prior to surgeryVisual Analogue Scale (VAS) for hunger, thirst and well-being outcomes, blood loss, aspiration, breastfeeding, neonatal outcomes, and maternal complications
Clark, 2020UKNot mentioned94Oral 800 ml of 12% carbohydrate on the previous evening and another 400 ml 2 h prior to surgery. An extra 400 ml or further 400 ml 2 hours prior to surgery90Oral 800 ml of water on the previous evening and another 400 ml 2 h prior to surgery. An extra 400 ml or further 400 ml 2 hours prior to surgeryUrinary ketone level, dominant hand grip strength, anxiety score, hunger and thirst scores, and length of hospital stay
He et al. 2021 [19]ChinaSpinal anesthesia30Oral 400 ml of 12.5% carbohydrate (50.9 kcal/100 mL) 2 hours before the surgery29Oral 400 ml clear water 2 hours before the surgery29Fasting for 10.5 hoursPostoperative insulin resistance, plasma glucose and insulin levels, VAS for thirst and hunger, the occurrences of nausea and vomiting, time of flatus, postoperative fever, Apgar score, and blood glucose level
Ningning Liu, 2020ChinaEpidural anesthesia, a combination of epidural and lumbar anesthesia43Oral 300 mL 7.5% carbohydrate (30.5 kcal/100 mL) 2 hours before induction of anesthesia42Oral 300 mL warm water 2 hours before induction of anesthesiaBlood glucose, serum insulin, hunger and thirst scores, and gastrointestinal function parameters
Yuan Shi, 2020ChinaContinuous epidural anesthesia25Oral 300 mL of 14.2% carbohydrate25Oral 300 mL of water25Fasting for 6 hoursVAS for thirst, hunger, and anxiety level, the gastric antral cross-sectional areas, insulin resistance, blood glucose, and insulin levels
Yang et al. 2021 [21]ChinaCombined spinal-epidural anesthesia39Oral 300 mL of 14.1% carbohydrate (57.6 kcal/100 mL) at 2 hours before surgery40Oral 300 mL of distilled water at 2 hours before surgery39Fasting, drinking, or eating on the day of the operationCore body temperature and body surface temperature, the incidence of intraoperative hypotension, vomiting, and shivering, amount of bleeding
Cheng et al. 2022 [15]ChinaCombined spinal-epidural anesthesia38Oral 300 mL of 14.1% carbohydrate (57.6 kcal/100 mL) 2 h before the operation37Oral 300 mL of distilled water 2 h before the operation37Fasting, drinking, or eating on the day of the operationThe time to colostrum and exhaust, the incidence of vomiting, VAS of pain, vaginal bleeding volume, and complications (urinary retention, fever, or intestinal obstruction)

CHO, carbohydrate; VAS, Visual Analog Scale.