Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes

Figure 1

Representative cell viability assay of primary astrocytes. Representative phase-contrast microscopic images (10X) showing young human fetal astrocytes in primary cultures without any additives (a) and dying and detaching young astrocytes in cultures containing 300 μM propofol in DMSO ((b), arrows). (c) Senescent human astrocytes show morphological changes indicative of cellular senescence, including flattened cell bodies and the presence of cytoplasmic vacuoles.

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(b)

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