AIDS Research and Treatment / 2010 / Article / Tab 2

Research Article

Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia

Table 2

Association between the four measures of adherence and virological failure in the overall population.

Virological failure: (%)OR [95% CI]

Self-report questionnaire (all three items)*

100% adherent22363 (28.2)1
At least one missed HAART dose3411 (32.3)1.21 [0.56–2.64].62

Visual analog scale*

1018454 (29.3)1
96218 (29.1)0.98 [0.52–1.85].70
<9112 (18.2)0.54 [0.11–2.55]

Antiretroviral drug concentrations (ng/mL)

1000 for EFV or 3000 for NVP24161 (25.3)1
<1000 for EFV or <3000 for NVP1813 (72.2)7.67 [2.63 –22.40]<.0001

Macrocytosis (MCV 100 fL)**

Yes22962 (27.1)1
No2312 (52.1)2.94 [1.23–7].015

Self-report questionnaire plus macrocytosis

100% adherent20056 (28)1
At least one mistake5018 (36)1.44 [0.75–2.78].27

Self-report questionnaire plus drug assays

100% adherent20954 (25.8)1
At least one mistake4820 (41.7)2.05 [1.07–3.93].031

OR: odds ratio; CI: confidence interval, *Available for 257 patients, **Available for 252 patients.

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