Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy

Table 2

Thyroid workup and management (FT4: free T4, TSH: thyroid stimulating hormone, TPO-Ab: thyroid peroxidase antibody, TBG-Ab: thyroglobulin antibody, PTU: propylthiouracil).

No.	Thyroid Work Up	Time till symptoms	Symptoms	Previous thyroid condition	HCV coinfection	Treatment	History of autoimmune disease
(1)	FT4: 7.43 ng/dL; TSH < 0.01 MIU/mL TPO-Ab: 46.7 IU/mL; TBG-Ab < 1 IU/mL	44 months	Thyromegaly, lid lag, weight loss, alopecia, diarrhea, and tachycardia	No	No	Methimazole I-131 radioablation	No
(2)	TSH < 0.01 MIU/mL FT4: 3.3 ng/dL; Diffuse uptake on thyroid scan	53 months	Tremor, weight loss, exophthalmos, and thyromegaly	No	No	Methimazole atenolol	No
(3)	TSH < 0.004 MIU/mL; T4: 12.2 ng/dL; TBG-Ab: 40 IU/mL	31 months	Weight loss, tremor, exophthalmos, lid lag, and fatigue	No	No	PTU metoprolol	No
(4)	Not available	19 months	Tremors, weight loss, loss of appetite, thyromegaly, and exophthalmos	No	No	methimazole metoprolol	No