AIDS Research and Treatment / 2012 / Article / Tab 2

Research Article

Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection

Table 2

(a) Analysis of the association of demographic and HIV-related characteristics with late presentation. (b) Analysis of the association of T-cells subpopulations with late presentation.
(a)

ParametersLate presenters (CD4 T cell 350 and/or AIDS defining event)P
No (145, 53%)Yes (130, 47%)

Age, years*36 (30–43)41 (34–50)0.0001
Gender, male°120 (83)105 (81)0.669
Risk group°0.020
 Homosexual93 (64)59 (45)
 Heterosexual47 (32)64 (49)
 IDUs4 (3)6 (5)
 Other1 (1)1 (1)
Migrants°30 (21)43 (33)0.020
HCV coinfection°7 (5)9 (7)0.382
Calendar year of presentation°0.385
 200752 (36)33 (25)
 200832 (22)29 (22)
 200930 (21)31 (24)
 201028 (19)33 (25)
 January–March 20113 (2)
HIV-RNA log10 cp/mL*4.33 (3.24–4.96)4.54 (1.77–5.26)0.884
CD4+ T cells/μL*538 (441–698)218 (100–290)0.0001

(b)

T-cells immunophenotypesLate Presenters (CD4 T cell 350 and/or AIDS defining event)P
No (145, 53%)Yes (130, 47%)

CD4+ T cells %*28 (23–35)14 (10–21)0.0001
CD8+ T cells %*45 (38–54)57 (51–63)0.0001
CD4+CD127+ cells %*19 (12–24)7 (4–12)0.0001
CD8+CD127+ cells %*10 (8–15)11 (7–19)0.346
CD4+CD95+ cells %*2 (1–4)2 (1–3)0.898
CD8+CD95+ cells %*2 (1–3)3 (2–5)0.0001
CD8+CD38+ cells %*5 (2–9)9 (3–18)0.0001
CD8+CD38+CD45R0+ cells %*9 (5–16)15 (10–25)0.0001

Data are presented as median, (interquartile range, IQR) and °absolute number, (%). IDUs: injection drug users; migrants: people who were born outside the European community (including people from Eastern Europe, Africa, Asia, and Latin America); HCV: hepatitis C virus.
Comparison between categorical variables was assessed by Pearson’s Chi square and between continuous variables by nonparametric Mann-Whitney -test. was considered to denote statistical significance.

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