Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F₁ Mice

Table 4

Relative mitochondrial DNA (mtDNA) copy number in the livers of B6C3F₁ mice.

AZT dose (mg/kg/d)	B6C3F1 mice
	Male	Female
0	12.02±4.87 (𝑁=6)	8.46±1.51 (𝑁=6)
400	8.46±3.83 (𝑁=5)	7.37±1.57 (𝑁=6)
500	18.69±8.26 (𝑁=6)	8.95±1.29 (𝑁=6)
600	11.66±7.05 (𝑁=5)	10.08±1.75 (𝑁=5)

The mtDNA copy number was based on quantitative real-time PCR measurements of D-loop concentration relative to the concentration of ΦX174RF added at a fixed concentration before DNA extraction. The numbers in parentheses indicate the number of animals in the group. Values are presented as the mean ± SEM (Standard error of the mean).