Clinical Study

Loss to Followup in HIV-Infected Patients from Asia-Pacific Region: Results from TAHOD

Table 1

Receiver operating characteristic (ROC) analysis for the best-performing definition for loss to followup.

Cutoff (days)Sensitivity (%)Specificity (%)Area under ROCCutoff (days)Sensitivity (%)Specificity (%)Area under ROC

1099.6716.9758.3216090.9690.7790.87
2099.0224.3261.6717090.6491.4491.04
3098.0531.3164.6817590.6492.0591.34
4096.8239.9068.36180 90.55 92.26 91.41
5096.3449.5272.9318590.2392.5391.38
6095.7757.2076.4819089.3393.0191.17
7095.2865.5280.4020088.5293.4490.98
8095.1171.2683.1921087.7994.1390.96
9094.7177.6286.1624085.2695.2590.26
10094.2280.9187.5727083.5596.4389.99
12093.2486.1889.7130082.0097.0489.52
15091.5390.1790.8536578.9997.7388.36

True LTFU defined as no patient followup in the 12 month prior to 31 March 2010. Each cutoff used as a potential definition of LTFU was the days between last clinical visit and 31 March 2009 in the March 2009 data transfer. The sensitivity and specificity of each cutoff in identifying true LTFU were calculated, and the optimal cutoff identified based on ROC analysis.