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AIDS Research and Treatment
Volume 2012, Article ID 574656, 8 pages
Review Article

Determinants of Adherence to Antiretroviral Therapy among HIV-Infected Patients in Africa

1Department of Public Health, College of Health Sciences, Haramaya University, P.O. Box 1014, Harar, Ethiopia
2Department of Epidemiology and Biostatistics, Jimma University, P.O. Box 24414, Jimma, Ethiopia

Received 15 October 2011; Accepted 15 December 2011

Academic Editor: Gene D. Morse

Copyright © 2012 Ayalu A. Reda and Sibhatu Biadgilign. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. There are only a few comprehensive studies of adherence to ART and its challenges in Africa. This paper aims to assess the evidence on the challenges and prospects of ART adherence in sub-Saharan Africa. Methods. The authors reviewed original and review articles involving HIV-positive individuals that measured adherence to ART and its predictors in the past decade. Findings. Against expectations, sub-Saharan Africa patients have similar or higher adherence levels compared to those of developed countries. The challenges to ART adherence include factors related to patients and their families, socioeconomic factors, medication, and healthcare systems. Conclusion. Despite good adherence and program-related findings, antiretroviral treatment is challenged by a range of hierarchical and interrelated factors. There is substantial room for improvement of ART programs in sub-Sahara African countries.