Research Article
Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP
Table 1
The greatest initial NVP concentrations of every virus, IC50 (μM) of every virus and the increased NVP resistance compared to pNL4-3.
| | Virus no. | Mutation patterns | Greatest concentration of NVP (μM) | IC50 (μM) | Median fold of IC50 increased compared to pNL4-3 (±S.D.) |
| | 101Q-1 | K101Q/Y181C/H221Y | 1000 | | 3740.8 (±314.1) | | 101Q-2 | K101Q/Y181C | 200 | | 1490.9 (±354.4) | | 101Q-3 | K101Q/H221Y | 2 | | 4.4 (±1.2) | | 101Q-4 | K101Q | 0.5 | | 1.2 (±0.2) | | 179D-1 | V179D/Y181C/H221Y | 500 | | 5090.6 (±744.6) | | 179D-2 | V179D/Y181C | 500 | | 1413.0 (±269.8) | | 179D-3 | V179D/H221Y | 5 | | 13.4 (±1.9) | | 179D-4 | V179D | 1.25 | | 4.6 (±1.3) | | 103N-1 | K103N/Y181C/H221Y | 1000 | | 5859.3 (±1648.2) | | 103N-2 | K103N/Y181C | 1000 | | 2802.4 (±124.1) | | 103N-3 | K103N/H221Y | 50 | | 139.2 (±8.2) | | 103N-4 | K103N | 25 | | 63.8 (±3.1) | | Con-1 | | 1 | | |
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