Research Article
Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP
Table 2
Contribution of H221Y, Y181C, H221Y/Y181C to an increased NVP resistance based on various mutation profiles.
| Aimed mutation | Base mutation profile | Increased fold of IC50 (±S.D.) |
| H221Y | K101Q/Y181C | 2.2 (±0.9) | H221Y | K101Q | 3.2 (±0.3) | H221Y | V179D/Y181C | 3.6 (±0.5) | H221Y | V179D | 3.0 (±0.4) | H221Y | K103N/Y181C | 2.1 (±0.5) | H221Y | K103N | 2.2 (±0.1) | Y181C | K101Q/H221Y | 759.1 (±41.9) | Y181C | K101Q | 1297.0 (±289.1) | Y181C | V179D/H221Y | 390.0 (±101.6) | Y181C | V179D | 312.5 (±45.3) | Y181C | K103N/H221Y | 41.9 (±8.4) | Y181C | K103N | 47.9 (±4.2) | Y181C/H221Y | K101Q | 3444.6 (±834.5) | Y181C/H221Y | V179D | 1132.6 (±180.4) | Y181C/H221Y | K103N | 100.6 (±32.5) |
|
|