AIDS Research and Treatment / 2012 / Article / Tab 3

Clinical Study

Short-Term Rationing of Combination Antiretroviral Therapy: Impact on Morbidity, Mortality, and Loss to Follow-Up in a Large HIV Treatment Program in Western Kenya

Table 3

Cox proportional (unadjusted and adjusted) hazard ratios and 95% confidence intervals for morbidity, loss to follow-up, and mortality.

MorbidityLoss to follow-upMortality
UnadjustedAdjustedbUnadjustedAdjustedbUnadjustedAdjustedb

CovariateHR
(95% CI)
P valueHR
(95% CI)
P valueHR
(95% CI)
P valueHR
(95% CI)
P valueHR
(95% CI)
P valueHR
(95% CI)
P value

Enrolled during cap period0.93
(0.83, 1.03)
0.1620.92
(0.82, 1.03)
0.1521.19
(1.11, 1.27)
<0.0011.12
(1.04, 1.22)
0.0041.31
(1.16, 1.48)
<0.0011.21
(1.06, 1.39)
0.006
Use of Cotrimoxazole or Dapsonea0.66
(0.58, 0.76)
<0.0010.67
(0.55, 0.80)
<0.0010.39
(0.36, 0.42)
<0.0010.58
(0.52, 0.65)
<0.0010.49
(0.42, 0.56)
<0.0010.46
(0.37, 0.57)
<0.001
TB treatmenta0.82
(0.72, 0.93)
0.0030.68
(0.59, 0.78)
<0.0011.04
(0.97, 1.12)
0.2990.99
(0.90, 1.09)
0.8501.11 (0.97, 1.27)0.1360.84
(0.72, 0.99)
0.033
Male gender0.98 (0.88, 1.09)0.7180.95
(0.85, 1.07)
0.4181.05
(0.98, 1.12)
0.1871.01
(0.93, 1.10)
0.7601.48 (1.31, 1.67)<0.0011.36
(1.19, 1.57)
<0.001
Age (per year increase)a1.00
(0.99, 1.00)
0.3331.00
(0.99, 1.01)
0.7720.99 (0.98, 0.99)<0.0010.99
(0.98, 0.99)
<0.0011.00
(1.00, 1.01)
0.3881.00
(1.00, 1.01)
0.484
CD4 (per cell increase)a0.999
(0.999, 1.000)
0.0060.998
(0.998, 0.999)
<0.0010.999
(0.999, 0.999)
<0.0010.999
(0.999, 0.999)
<0.0010.995
(0.994, 0.996)
<0.0010.995
(0.994, 0.996)
<0.001
WHO Stage Ia1.001.001.001.001.001.00
WHO Stage IIa1.24
(1.01, 1.51)
0.0381.23
(1.01, 1.51)
0.0440.95
(0.83, 1.09)
0.4540.96
(0.83, 1.10)
0.5431.19 (0.87, 1.63)0.2791.10
(0.80, 1.50)
0.572
WHO Stage IIIa1.49
(1.26, 1.78)
<0.0011.64
(1.36, 1.96)
<0.0011.32
(1.18, 1.49)
<0.0011.24
(1.10, 1.40)
<0.0012.62
(2.02, 3.40)
<0.0012.44
(1.87, 3.19)
<0.001
WHO Stage IVa2.10
(1.68, 2.62)
<0.0012.55
(2.01, 3.24)
<0.0012.08
(1.80, 2.40)
<0.0011.98
(1.70, 2.31)
<0.0014.51
(3.37, 6.04)
<0.0014.41
(3.24, 5.99)
<0.001
Urban Clinica0.99
(0.89, 1.10)
0.8570.99
(0.88, 1.11)
0.8561.05
(0.99, 1.12)
0.1281.02
(0.94, 1.10)
0.6510.76
(0.68, 0.87)
<0.0010.80
(0.70, 0.92)
0.002
Travel time < 30 min1.001.001.001.001.001.00
Travel time 30–60 min0.93
(0.80, 1.07)
0.3050.95
(0.81, 1.10)
0.4911.13
(1.03, 1.24)
0.0091.14
(1.03, 1.27)
0.0141.36
(1.14, 1.62)
<0.0011.18
(0.97, 1.43)
0.098
Travel time 1-2 hr1.04
(0.90, 1.21)
0.5981.01
(0.86, 1.18)
0.9081.07
(0.97, 1.17)
0.2041.07
(0.96, 1.20)
0.2311.30
(1.08, 1.56)
0.0051.09
(0.89, 1.34)
0.390
Travel time > 2 hr0.98
(0.83, 1.17)
0.8460.93
(0.78, 1.12)
0.4641.34
(1.20, 1.48)
<0.0011.40
(1.24, 1.58)
<0.0011.38
(1.12, 1.68)
0.0021.16
(0.93, 1.45)
0.192

aAt enrollment.
bAdjusted for all covariates.

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