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AIDS Research and Treatment
Volume 2014 (2014), Article ID 724958, 4 pages
http://dx.doi.org/10.1155/2014/724958
Clinical Study

Plasma and Intracellular Antiretroviral Concentrations in HIV-Infected Patients under Short Cycles of Antiretroviral Therapy

1Institut de Chimie de Nice UMR 7272, Université Nice Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France
2Laboratory of Pharmacology-Toxicology, AP-HP, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France
3Immunology and Virology Unit, AP-HP, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France

Received 30 May 2014; Revised 17 October 2014; Accepted 17 October 2014; Published 9 November 2014

Academic Editor: David Katzenstein

Copyright © 2014 Laura Zehnacker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Study of plasma and intracellular concentrations of atazanavir, lopinavir, nevirapine, and efavirenz was conducted on 48 patients under short cycles of antiretroviral therapy. Intracellular concentrations (IC) were still measurable for all drugs after 85 h or 110 h drug intake despite the absence of drug in plasma for atazanavir and lopinavir. A linear relationship between plasma and intracellular efavirenz was observed. Further studies to fully understand the impact of IC in the intermittent antiviral treatment are required.