Research Article
Relationships between Serum Levels of Atazanavir and Renal Toxicity or Lithiasis
Table 2
Characteristics of patients who had renal colic are compared to those of who did not have renal colic.
| | | Renal colic | Without renal colic | value | | () | () |
| | Gender (M/F) (%) | 7/2 (77.8/22.2) | 65/24 (73.03/26.97) | 0.81 | | Mean age (years) | 46.2 | 45.2 | 0.74 | | Grouped BMI (<20/20–30/>30) (%) | 4/4/1 (44.4/44.4/11.2) | 14/66/9 (15.73/74.16/10.11) | 0.66 | | Basal CD4 lymphocytes, median (cells/μL) | 706 | 547 | 0.27 | | Basal VL (log10cop/mL) (mean) | 1.7 | 2.5 | 0.07 | | Cumulative ATV exposures (months) | 25.5 | 25.9 | 0.95 | | Lithiasis before start of study () (%) | 2 (22.22) | 14 (15.73) | 0.74 | | Basal renal function by MDRD (mL/min/1.73 m2) | 82.2 | 99.9 | 0.03 | | Basal uric acid (mg/dL) | 2.9 | 0.4 | 0.22 | | Increase in bilirubin (mg/dL) (mean) | 0.42 | 0.70 | 0.74 | | Type of crystalluria (total) (%) | 66.6 | 16.8 | <0.001 | | Calcium oxalate (%) | 0 (0) | 6 (6.9) | | | Amorphous urate (%) | 3 (27.3) | 9 (10.3) | | | ATV (%) | 3 (27.3) | 0 (0) | | | Urine pH | 6.1 | 5.6 | 0.048 | | Time of ATV dosage (B/L/D) | 3/3/3 | 25/16/42 | 0.77 | | Mean levels of ATV (overall) (µg/L) | 1303 | 1161 | 0.67 | | B dosage patient levels | 368 | 594 | 0.55 | | L dosage patient levels | 1312 | 834 | 0.12 | | D dosage patient levels | 1921 | 1578 | 0.52 |
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: number; M/F: male/female; BMI: body mass index; MDRD: Modification of Diet in Renal Disease; B/L/D: breakfast, lunch, and dinner.
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