Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals

Table 2

Some reported frequencies of CYP2B6 polymorphism in different African populations.

Population	Frequency (%)	Number of subjects	Reference
African American	20	50	[48]
African American	36	85	[49]
African American	34	93	[152]
Tanzanians	36	95	[153]
Malawians	31 (15)	26	[60]
Ghanaians	46	42	[152]
Ghanaians	25	800	[78]
Ethiopians	45.5 (8.7)	262	[45]
Ivory coast	38	41	[152]
Sierra Leone	36	52	[152]
Senegal	60	10	[152]
Guinea	48	21	[152]
West Africa	42	166	[152]
West Africa	50	153	[49]
Yoruba (Ibadan, Nigeria)	35	78	[49]
South Africa	41 (23)	80	[154]
Xhosa (South Africa)	17	109	[155]
CMA (South Africa)	9	67	[155]
Botswana	36.6	101	[156]
Zimbabwe	49	71	[76]
Uganda	35.6	121	[63]
Uganda	29	7 males	[13]
Mozambique	7	78	[14]

GT (TT) and loss of function CYP2B618.