Review Article

Mortality and Its Predictors among HIV Infected Patients Taking Antiretroviral Treatment in Ethiopia: A Systematic Review

Table 3

Predictors of mortality.

Sr. numberAuthor, year of publicationPredictor variableAHR95% CI (upper limit, lower limit)

(1)Hambisa MT et al., 2013Age ≥ 403.0551.292–7.223
Baseline hemoglobin level0.5230.335–0.816
Poor ART adherence27.8488.928–86.863

(2)Tsehaineh B. et al., unpublishedOld age1.031.01–1.051
CD4 count at baseline0.9940.992–0.996
Weight at baseline0.9020.816–0.996
Bedridden functional status6.9044.005–11.902
Ambulatory functional status2.8771.899–4.360
Coinfection with TB1.9061.305–2.784
Substance use1.421.016–1.985

(3)Setegn et al., 2015Male2.671.74–4.10
Bedridden clients4.41.55–12.36
TB coinfected at ART initiation4.512.86–7.11
Primary education0.280.11–0.70
Secondary education0.340.154–0.728
WHO stage 10.160.08–0.33
WHO stage 20.340.16–0.73
WHO stage 30.240.13–0.43

(4)Biadgilign S. et al., 2012WHO stage IV3.191.51–6.76
Bedridden4.092.12–7.90
>10% weight loss from baseline4.931.20–20.41
CD40.400.17–0.93
Education2.791.26–6.16

(5)Kassa A. et al., 2012CD4 < 50 cells/μl1.801.17–2.83
WHO stage III1.461.03–2.08
WHO stage IV2.721.91–3.88
Those who developed TB after ART1.601.19–2.15
Ambulatory functional status1.441.07–1.93
Bedridden functional status2.952.10–4.13

(6)Seyoum D. et al., 2017Age > 353.81.6–9.1
Baseline weight0.930.90–0.97
Baseline WHO stage IV6.22.2–14.2
Low adherence to ART4.22.5–7.1

(7)Damtew B. et al., 2015Single marital status2.311.18–4.50
Bedridden functional status5.912.87–12.16
Advanced WHO stage7.363.17–17.12
BMI < 18.5 kg/m22.201.18–4.09
CD4 count < 50 cells/μL2.701.26–5.80
Severe anemia4.572.30–9.10
TB coinfection2.301.28–4.11

(8)Alemu AW and Sebastian MS, 2010Hemoglobin < 10 g/dL2.561.11–5.88
WHO stage IV5.132.33–11.33
Not on cotrimoxazole prophylaxis7.142.7–20.00

(9)Ayalew et al., 2014Age 30–400.490.28–0.85
Rural residency1.741.11–2.74
CD4 count0.9980.996–0.999
Weight0.9680.943–0.993
Not working functional status3.621.96–6.68
Lymphocyte count0.9690.945–0.994
WHO stage IV2.381.21–4.63
TB positive1.871.03–3.40

(10)Ahunie MA and Ebrahim EAAmbulatory functional status4.21.7–10.7
Bedridden functional status6.52.0–20.7
Poor antiretroviral drug adherence5.11.6–16.3

(11)Abebe N et al., 2014Baseline hemoglobin < 10 g/mm31.861.39–2.64
Ambulatory functional status2.721.90–3.90
Bedridden functional status2.381.32–4.27
WHO stages III and IV2.161.10–4.25
Poor adherence2.161.03–4.56
Fair adherence1.881.08–3.29
Unexplained chronic diarrhea1.531.09–2.15
Not on TB prophylaxis3.981.87–8.44

(12)Tadesse K et al., 2014Hemoglobin level < 11 mg/dl1.91.01–3.52
CD4 cell count < 50 cells/μl2.11.13–3.89
Male gender1.91.01–3.52
Weight < 40 kg2.31.24–4.55
Primary and lower level of education2.61.29–5.55

(13)Bedru A. and worku A, unpublishedPoor ART adherence3.923.13–4.90
Advanced WHO staging2.471.58–3.81
Being unemployed1.871.49–2.34
Moderate anemia1.861.35–2.56
Low CD4 count1.851.35–2.52

(14)Mengesha S et al., 2014WHO clinical stage2.991.26–5.31
Anemia5.542.58–11.86
Having past TB coinfection4.131.79–9.51

(15)Moshago T et al., 2012WHO clinical stage IV4.51.36–14.88
WHO clinical stage III3.21.06–10.24
History of TB coinfection1.251.03–1.53
Bedridden functional status2.632.05–3.37
Ambulatory functional status1.561.31–1.86

(16)Sapa et al., 2016BMI < 18.5 kg/m23.121.39–7.76
CD4 cell count < 50 cells/mm34.551.19–8.44
Drug addiction2.031.11–4.56
WHO stages III and IV11.258.67–17.96
Severe anemia5.143.12–9.65

(17)Kebebew K and Wencheko E, 2012CD4 cell count at baseline0.780.64–0.95
Employment status2.311.25–4.28
Ambulatory functional status2.011.02–3.98
Bedridden functional status3.361.73–6.50
WHO clinical stage III7.051.68–29.66
WHO clinical stage IV12.643.00–53.20
TB coinfection1.731.04–2.89
Presence of opportunistic infections8.991.24–65.09