Trends and Adaptive Optimal Set Points of CD4⁺ Count Clinical Covariates at Each Phase of the HIV Disease Progression

Figure 1

The study design. The CAPRISA 002 HIV negative cohort (phase 1: pre-HIV infection) screening involved 775 voluntary potential candidates of which 462 were already HIV positive and 313 initially eligible. Of the 313 HIV negative, only 245 were enrolled and the rest were excluded for various reasons according to the eligibility criteria. Eventually, 27 out of the 245 seroconverted and enrolled into follow-up care. Seroconverts from other CAPRISA studies (210) were also included into the follow-up care that resulted in a total of 237 patients for this study.