Immunologic Response of HIV-Infected Children to Different Regimens of Antiretroviral Therapy: A Retrospective Observational Study

Table 3

Random-effect linear regression analysis of trend of CD4+ count (slope, cells/mm³/6 month) at JMC, from April 10 to May 10, 2017.

Variables		n (%)	Unadjusted %β [95%CI]	value	Adjusted %β [95%CI]	value
Sex	Male	98 (54.75)	0
	Female	81 (45.25)	7.46[−13.61−28.53]	0.488
Age: median (IQR)	7 (4–9)	179 (100)	−0.56[−4.24−3.12]	0.765
BMI	Below 5^th centile	140 (78.21)	−19.45[−44.56−5.70]	0.130	−5.18[−22.99−12.63]	0.569
	Above 5^th centile	39 (21.79)	0		0
Weight for height	≤70%	36 (20.11)	−31.84[−57.96− (−5.72)]	0.017	2.31[−18.10−22.72]	0.825
	70–85%	14 (7.82)	−9.84[−48.62−28.94]	0.619	5.91[−21.17−32.99]	0.669
	≥85%	129 (72.07)	0		0
In care of the child	Mother	24 (13.41)	16.91[−13.74−47.57]	0.280
	Others	155 (86.59)	0
Maternal status	Dead	33 (18.44)	−3.244[−30.53−24.06]	0.816
	Live	146 (8156)	0
Maternal serostatus	Unknown	18 (10.06)	−5.01[−40.54−30.53]	0.782
	Negative	161 (89.94)	0
Paternal status	Dead	47 (26.26)	0.32[−23.39−24.03]	0.979
	Live	132 (73.74)	0
Residence	Urban	134 (78.86)	0
	Rural	45 (25.14)	−6.59[−31.04−17.87]	0.598
ART group	ABC	87 (48.60)	0		0
	AZT	92 (51.40)	30.42[9.89–50.94]	0.004	20.51[6.37−34.65]	0.004
CD4 count	162 (117–221)	179 (100)	0.72[0.62–0.82]	≤0.001	0.55[0.49−0.69]	≤0.001
OI occurred	No	121	0		0
	Yes	58	−49.12[−70.49− (−27.74)]	≤0.001	−18.65[−5.49−42.78]	0.130
Viral load	≤1000 copies/ml	146 (83.43)	0
	>1000 copies/ml	29 (16.57)	−50.21[−77.71− (−22.71)]	≤0.001	−27.68[−47.75− (−7.61)]	0.007
WHO stage	Stage I	11 (6.15)	0		0
	Stage II	64 (35.75)	−31.43[−73.23−10.37]	0.141	−28.63[−64.05−6.71]	0.112
	Stage III	87 (48.60)	−94.64[−136.08− (−53.19)]	≤0.001	−47.61[−84.27− (−10.96)]	0.011
	Stage IV	17 (9.50)	−151.41[−199.26− (−103.56)]	≤0.001	−73.54[−118.27− (−28.81)]	0.001
Nutritional status	Normal	102 (57.00)	0		0
	SAM	77 (43.00)	−38.79[−59.28− (−18.30)]	≤0.001	−13.42[−35.34−8.50]	0.230
TB treatment	No	166 (92.74)	0		0
	Yes	13 (7.26)	−61.14[−103.84− (−18.43)]	0.005	−32.58[−65.18−0.21]	0.050