AIDS Research and Treatment / 2020 / Article / Tab 1

Research Article

Overweight and Obesity among Recipients of Antiretroviral Therapy at HIV Clinics in Gaborone, Botswana: Factors Associated with Change in Body Mass Index

Table 1

Standard first- and second-line ART regimens in Botswana at the time of the study.

First-line regimenFirst-line modificationsSecond-line regimenSecond-line modifications

AZT + 3TC (CBV) + EFVTDF renal toxicity without CVD risk: ABC/3TC/DTG (If rash: consult HIV specialist)TDF + FTC + ALUAZT anemia and/or TDF renal toxicity: ABC/3TC/DTG
CNS toxicity and/or Hepatic toxicity: TRU/DTG
TDF + FTC (or 3TC) + EFVCBV + ALUIf anemic ABC + 3TC + ALU
TDF + FTC (or 3TC)+NVP
D4T + 3TC + EFVTDF + FTC = ALUIf renal insufficiency but no anemia: CBV + ALU
D4T + 3TC + NVP
DDI + 3TC + NVPIf renal insufficiency and anemia: ABC + 3TC + ALU

AZT = zidozudine; 3TC = lamivudine; EFV = efavirenz; CNS = central nervous system; CBV = combivir; DDI = didanosine; NVP = nevirapine; DTG = dolutegravir; TRU = truvada; ABC = abacavir; TDF = tenofovir; FTC = emtricitabine, and ALU = aluvia. The third-line regimen comprised other alternative combination or salvage therapy. This was deployed in case of failure of both the standard first- and second-line regimens.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.