AIDS Research and Treatment

HIV-Infected Late Presenter Patients

Publishing date
15 Nov 2011
Submission deadline
15 May 2011

1Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, Milan, Italy

2National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Via Portuense 270, 00149 Rome, Italy

3Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases L. Spallanzani IRCCS, Via Portuense 292, 00149 Rome, Italy

4Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

5Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milan-Bicocca, Monza, Italy

6Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK

7British Columbia Centre for Excellence, HIV, AIDS Research, Vancouver, BC, Canada

HIV-Infected Late Presenter Patients


An increasing proportion of HIV-infected individuals are diagnosed late, with CD4 T-cell counts below 350 cells/mm3 or with a symptomatic HIV disease. These patients, known as late presenters, make up to 50-60% of patients presenting for first care throughout Europe and North America, with quite a large range being mainly due to differences in definitions and geographical settings. Several epidemiological factors have been thus far associated with late HIV diagnosis that include older patients, females, homosexual men, and migration.

Late presenters represent one of the major challenges in the clinical management of HIV/AIDS. Indeed, it has been well documented that they display an increased risk of HIV- and non-HIV-related clinical events and death. Furthermore, lowest ranges of CD4 counts at HAART initiation are associated with a more relent and overall less efficient immune reconstitution even after years of virologically suppressive HAART.

Corollary to these findings is the need for the most careful therapeutic choice for these patients, also taking into account the risks of transmitted resistance, viral evolution, archived mutations, and reemerging mutation after drug exposure that might be particularly harmful in these critical patients.

We are particularly interested in manuscripts that help better detail the phenomenon of late diagnosis and consequent late presentation throughout the world, with respect to epidemiological, clinical, immunopathogenetic, and virological aspects.

In particular, we would particularly welcome papers reporting epidemiological data on HIV late presentations in diverse contexts, further aiming to understand different risk factors/behaviors that could possibly impact on preventive strategies. We are also interested in papers dealing with clinical and therapeutical issues and studies describing efficacy of specific therapeutic approaches including immune adjuncts to HAART. Potential topics include, but are not limited to:

  • Definition and epidemiology
  • Clinical and social aspects
  • Immunopathogenetic issues
  • Tropism and viral resistance
  • Treatment option and response to therapy

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2012
  • - Article ID 902679
  • - Editorial

HIV-Infected Late Presenter Patients

Antonella D'Arminio Monforte | Andrea Antinori | ... | Julio S. Montaner
  • Special Issue
  • - Volume 2012
  • - Article ID 182672
  • - Research Article

Comparing Measures of Late HIV Diagnosis in Washington State

Laura Saganic | Jason Carr | ... | Ann Duerr
  • Special Issue
  • - Volume 2012
  • - Article ID 314849
  • - Research Article

Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection

Francesca Bai | Camilla Tincati | ... | Giulia Marchetti
  • Special Issue
  • - Volume 2012
  • - Article ID 725412
  • - Research Article

Imputation of the Date of HIV Seroconversion in a Cohort of Seroprevalent Subjects: Implications for Analysis of Late HIV Diagnosis

Paz Sobrino-Vegas | Santiago Pérez-Hoyos | ... | Julia del Amo
  • Special Issue
  • - Volume 2012
  • - Article ID 869841
  • - Research Article

CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009

Kate Buchacz | Carl Armon | ... | John T. Brooks
  • Special Issue
  • - Volume 2012
  • - Article ID 757135
  • - Research Article

The Direct Medical Costs of Late Presentation ( ) of HIV Infection over a 15-Year Period

Hartmut B. Krentz | M. John Gill
AIDS Research and Treatment
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