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Advances in Urology
Volume 2008, Article ID 173694, 2 pages
Case Report

Treatment of Low-Grade Bulbar Transitional Cell Carcinoma with Urethral Instillation of Mitomycin C

1School of Medicine, Wayne State University, Detroit, MI 48201, USA
2Chief of Urology, Detroit Receiving Hospital, Wayne State University, Detroit, MI 48201, USA

Received 8 April 2008; Accepted 8 September 2008

Academic Editor: Sangtae Park

Copyright © 2008 Emmanuel J. Melonakos and Richard A. Santucci. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 63-year old man was referred to us after three rapid recurrences of low-grade urethral papillary transitional cell carcinoma of the bulbar urethra, after repeated primary excision. Cystoscopy confirmed 3-4 low-grade urethral transitional cell carcinomas, which were subsequently fulgurated. After urethral healing, a solution of Mitomycin C (40 mg/80 cc) was instilled into the urethra for fifteen minutes and held in place with a penile clamp. Urethral instillations were repeated weekly for six weeks. The patient is currently disease-free more than one year and three months posttreatment. This case highlights the successful treatment of urethral carcinoma with topical chemotherapy, which is usually reserved for the bladder, using a slight modification of standard technique.