Research Article

Multifocal Renal Cell Carcinoma: Clinicopathologic Features and Outcomes for Tumors 4 cm

Table 2

Clinical and pathologic features.

Solitary N = 1053Multifocal N = 60
Feature N (%) P-value

Age at Surgery (years)
<65 554 (52.6)23 (38.3).031
≥65499 (47.4)37 (61.7)
Sex
Female339 (32.2) 11 (18.3).025
Male714 (67.8)49 (81.7)
Symptoms at presentation
Absent582 (55.3)39 (65.0).140
Present471 (44.7)21 (35.0)
Constitutional symptoms at presentation
Absent893 (84.8)49 (81.7).512
Present160 (15.2)11 (18.3)
ECOG Performance status (N = 903)
0749 (88.4)50 (89.3).846
≥198 (11.6)6 (10.7)
Type of Surgery
Open radical nephrectomy532 (50.5)41 (68.3).007
Open nephron-sparing surgery460 (43.7)16 (26.7)
Laparoscopic radical nephrectomy23 (2.2)3 (5.0)
Laparoscopic nephron-sparing surgery38 (3.6)0
2002 Primary tumor classification
pT1a1020 (96.9)59 (98.3)1.00
pT3a20 (1.9)1 (1.7)
pT3b11 (1.0)0
pT3c2 (0.2)0
RCC Nuclear grade
1147 (14.0)6 (10.0).672
2673 (63.9)40 (66.7)
3221 (21.0)14 (23.3)
412 (1.1)0
Coagulative tumor necrosis
Absent921 (87.5)54 (90.0).562
Present132 (12.5)6 (10.0)
Sarcomatoid Differentiation
Absent1048 (99.5)60 (100.0)1.00
Present5 (0.5)0