A Review of the Effect of Injected Dextranomer/Hyaluronic Acid Copolymer Volume on Reflux Correction Following Endoscopic Injection

Table 2

Studies investigating the effect of injected Dx/HA volume on VUR correction.

Series	Refluxing units; mean	Mean	Volume injected (mL)	Method of statistical	Success by	Effect of volume of
	Dx/HA volume (mL)	grade	success/failures	analysis	grade (%)	injected Dx/HA
Kirsch 2003	292	2.6	S: 0.9±0.3	Univariate	I 90; II 82;	NS
	0.83±0.03		F: 0.9±0.2		III 73; IV 65
Kirsch 2004	119		S: 1.0		I 100; II 90;	Higher
modified	>0.9	2.8	F: 1.5	Univariate	III 91; IV 89	volume
STING						significant
Lavelle	80	NA	S: 0.8	Univariate	I 82; II 84;	NS
2005	NA		F: 0.9		III 77; IV 73
Routh	225 pts	2.4	S: 0.8 (0.4–2.0)	Univariate	I 63; II 72; III 57;	NS
2006	0.8 (0.3–2.0)		F: 0.8 (0.3–1.8)		IV 14 (By patients)
		2.6	NA	Studied as categorical	I 100; II 83;	Lower (<0.5)
Yucel	259			variable with cutoff	III 73;	volume
2007	0.54±0.2			</>0.5 mL using	IV 53,	significant
				multivariable analysis	V 29
		2.3	NA	Studied as categorical	I 83;	NS
Routh	453			variable with cut off	II 82;
2007	0.93 (0.2–3.5)			</>1 mL using	III 66;
				multivariable analysis	IV 53
		3			I 100,	Higher
Dave 2007	196		S: 0.9±0.2	Studied as continuous	II 75;	volume
(Accepted J	0.8±0.03		F: 0.6±0.2	variable using	III 57;	significant on
Urol)				multivariable analysis	IV 37;	multivariable
					V 46	analysis