Research Article

Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅 B Is a Steady Feature of Urinary Bladder Carcinogenesis

Table 2

Correlation of tumor grade with COX-2 immunostaining. High grade of bladder carcinomas exhibited strong COX-2 cytoplasmic expression. (Spearman correlation coefficient , ).

Tumor gradeNegativeWeakModerateStrongTotal (%)

Normal6 (20.7%)14 (48.3%)4 (13.8%)5 (17.2%)29 (100.0%)
Grade I3 (11.1%)8 (29.6%)9 (33.3%)7 (25.9%)27 (100.0%)
Grade II1 (3.3%)5 (16.7%)16 (53.3%)8 (26.7%)30 (100.0%)
Grade III5 (9.3%)15 (27.8%)23 (43.4%)11 (18.9%)54 (100.0%)

Total (%)15 (10.7%)42 (30.0%)52 (37.1%)31 (21.1%)140 (100.0%)