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Advances in Urology
Volume 2011, Article ID 489496, 6 pages
Research Article

Evaluation of Effectiveness of Vitamins C and E on Prevention of Renal Scar due to Pyelonephritis in Rat

1Department of Pediatrics, Shiraz Nephrology Urology Research Center, Jahrom University of Medical Sciences Jahrom, Iran
2Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences Shiraz, Iran
3Department of Bacteriology and Virology, Medical School, Shiraz HIV/Aids Research Center (SHARC), Shiraz University of Medical Sciences, Shiraz, Iran

Received 17 June 2010; Accepted 31 October 2010

Academic Editor: Ranjiv Mathews

Copyright © 2011 Fatemeh Emamghorashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim was evaluation of the effects of cosupplementation of, vitamins E and C, in preventing renal scarring in acute pyelonephritis. Animals and Treatments. Sixty rats were used, bacteria was injected through kidney. The rats were arranged randomly in 3 groups of 20 rats each. Rats in groups 1 and 2 were given once-daily intraperitoneal injections of gentamicin for ten consecutive days, beginning on the third day after inoculation. In group 2, vitamins E and C cotreatment and in group 3, vitamins E and C cotreatment without gentamicin injection were started. Three rats in each group were killed 24 hours after the inoculation (for infection and inflammation document) and forty-eight hours after the antibiotic injection (for efficacy of treatment). After eight weeks, the rest of rats were killed, and kidneys evaluated for percent of scaring. Result. There was also significant difference of degree of scar formation (1.4 and 3.4% versus 8.6%, 𝑃 = . 0 0 1 ). The group which received gentamicin only had moderate to severe scaring, but the two groups which received vitamin C and vitamin E showed no or mild renal scaring. Conclusion. The study showed that administration of antioxidants can protect scaring due to pyelonephritis with or without antibiotic administration.