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Advances in Urology
Volume 2011, Article ID 872057, 9 pages
Clinical Study

Nonsurgical Transurethral Radiofrequency Collagen Denaturation: Results at Three Years after Treatment

1Illinois Urogynecology, LTD., 5716 West 95th Street, Oak Lawn, IL 60453-2345, USA
2Atlanta Urogynecology Associates, Alpharetta, GA 30005, USA
3SOGA, Houston, TX 77004, USA
4Regional Urology, LLC, Shreveport, LA 71106, USA
5North Shore Women's Health, Great Neck, NY 11021, USA
6Alabama Research Center, LLC, Birmingham, AL 35209, USA

Received 6 July 2011; Accepted 27 September 2011

Academic Editor: James A. Brown

Copyright © 2011 Denise M. Elser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To assess treatment efficacy and quality of life in women with stress urinary incontinence 3 years after treatment with nonsurgical transurethral radiofrequency collagen denaturation. Methods. This prospective study included 139 women with stress urinary incontinence due to bladder outlet hypermobility. Radiofrequency collagen denaturation was performed using local anesthesia in an office setting. Assessments included incontinence quality of life (I-QOL) and urogenital distress inventory (UDI-6) instruments. Results. In total, 139 women were enrolled and 136 women were treated (mean age, 47 years). At 36 months, intent-to-treat analysis ( ) revealed significant improvements in quality of life. Mean I-QOL score improved 17 points from baseline ( ), while mean UDI-6 score improved (decreased) 19 points ( ). Conclusions. Transurethral collagen denaturation is a low-risk, office-based procedure that results in durable quality-of-life improvements in a significant proportion of women for as long as 3 years.