Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in Patients Who Underwent Retropubic Radical Prostatectomy

Table 3

Univariate and multivariate analysis in preoperative clinicopathological parameters.

Parameter	Univariate			Multivariates
	Hazard ratio	95% C.I.	𝑃 value	Hazard ratio	95% C.I.	𝑃 value
Age (continuous)	0.984	0.944–1.027	0.462			N.A.
Biopsy Gleason score
6 or less	1			1
7	1.269	0.663–2.430	0.472	0.658	0.281–1.543	0.336
8–10	4.103	2.199–7.656	<0.001	0.925	0.312–2.739	0.888
Clinical stage
T1	1			1
T2	1.719	1.048–2.819	0.032	1.191	0.652–2.177	0.567
T3	4.298	0.583–31.654	0.152	4.037	0.507–32.121	0.187
PSA at biopsy (ng/mL)
10 or less	1			1
10–20.0	1.543	0.892–2.668	0.121	0.961	0.398–2.324	0.930
Greater than 20	4.555	2.314–8.965	<0.001	0.892	0.258–3.089	0.857
% positive cores
Less than 34	1			1
34–50	1.139	0.444–2.920	0.787	1	0.333–2.999	1.000
50 or greater	2.340	1.384–3.956	0.002	1.807	0.949–3.444	0.072
Calculated cancer volume (mL)
2.0 or less	1			1
2.0–4.0	2.716	1.323–5.577	0.006	3.022	1.144–7.981	0.026
Greater than 4.0	7.116	3.595–14.085	<0.001	6.962	1.755–27.624	0.006

N.A.: not available. C.I: confidence interval.