Advances in Urology / 2012 / Article / Tab 1

Clinical Study

Clinical Results after High-Dose Intensity-Modulated Radiotherapy for High-Risk Prostate Cancer

Table 1

(a) The in-house developed Gastrointestinal toxicity scale, (b) The in-house developed Genitourinary toxicity scale.
(a)

GIGrade 1Grade 2Grade 3Grade 4

Abdominal crampsPresent, no therapyPeroral therapy, for example, SpasmolyticIV therapySurgery
DiarrheaPresent, no therapyPeroral therapy, for example, loperamideIV therapySurgery
FrequencyPresent, no therapyPeroral therapy, for example, loperamideIV therapy
Mucus lossPresent, no therapyNeed hygienic padsContinuous, invasive therapySurgery
Red blood lossNo therapy, frequency < 3x/weekFrequency ≥ 3x/weekInvasive therapy needed, for example, laser coagulationTransfusion need, surgery
UrgencyPresent, no therapyPeroral therapyIV therapy
IncontinencePresent, no therapyNeed hygienic pads (≤2/day)Need hygienic pads (>2/day)Surgery
Anal painPresent, no therapyLocal anesthetic for example, XylogelNarcotic analgeticaSurgery

(b)

GUGrade 1Grade 2Grade 3Grade 4

NocturiaTwice pretherapy, 2-3 times4–6 times (<1x hour)>6 times (more frequently than hourly)
FrequencyOnce/2 h, twice pretherapyOnce/1 hOnce/0.5 h (more frequent than hourly)
HematuriaMicroscopicIntermittent/moderateFrequent, gross hematuria/minor surgery needed (coagulation)Hemorrhagic cystitis requiring transfusion/
ulceration/
necrosis
DysuriaSlight, no medicationModerate, requiring local anesthetic (including bladder spasm)Dysuria, regular and frequent narcotics needed (including bladder spasm and pelvis pain)/severe/
stenosis/TUR or
dilatation
Bladder obstruction not secondary to clot passage
UrgencySlight, no medicationModerate, requiring local anesthetic (including bladder spasm)Severe requiring local anesthetic
Incontinence<weekly episodes<daily episodesPads/undergarments/
day
Refractory

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