Research Article
Clinical Significance of Amyloid Precursor Protein in Patients with Testicular Germ Cell Tumor
Table 2
Relationships between APP immunoreactivity and clinicopathological characteristics in TGCT patients (
).
| | Clinicopathological data | APP immunoreactivity | | Negative () | Positive () | P value |
| | Age (years ± SD) | 36.5 ± 10.7 | 30.0 ± 15.8 | 0.182 | | Tumor marker | | | | | LDH | | | 0.340 | | High | 20 | 7 | | | Normal | 31 | 6 | | | αFP | | | 0.00870 | | High | 14 | 9 | | | Normal | 37 | 4 | | | βhCG | | | 0.844 | | High | 29 | 7 | | | Normal | 22 | 6 | | | IGCCC | | | 0.222 | | Good | 6 | 1 | | | Intermediate | 2 | 3 | | | Poor | 0 | 0 | | | Stage | | | | | T stage | | | 0.0978 | | T1 | 36 | 6 | | | T2–4 | 15 | 7 | | | N stage | | | 0.444 | | N0 | 43 | 9 | | | N1–3 | 8 | 3 | | | Unknown | 0 | 1 | | | Venous invasion | | | 0.0414 | | Positive | 7 | 5 | | | Negative | 44 | 8 | | | Pathology | | | 0.0001 | | Benign testicular lesion | 31 | 0 | | | SGCT | 37 | 4 | | | NGCT | 14 | 9 | | Compared histological
types | | | | | SGCT versus NGCT | — | — | 0.00870 | SGCT versus benign
testicular lesion | — | — | 0.129 | NGCT versus benign
testicular lesion | — | — | 0.0002 |
|
|
APP: amyloid precursor protein, TGCT: testicular germ cell tumor, LDH: lactate dehydrogenase, αFP: alpha fetoprotein, βhCG: human chorionic gonadotropin β subunit, IGCCC: International Germ Cell Consensus Classification, SGCT: seminomatous germ cell tumor, NGCT: nonseminomatous germ cell tumor.
|
